NY-ESO-1 peptides which bind to class II molecules and uses thereof

摘要

The invention relates to peptides which consist of amino acid sequences found in the NY-ESO-1 molecule, which bind to MHC-Class II molecules. These can be used alone, or in combination with other peptides.

主权项

1. A composition useful in stimulating a T cell response comprising an isolated peptide consisting of the amino acid sequence set forth in SEQ ID NO: 2, wherein said peptide binds to an MHC-Class II molecule selected from the group consisting of HLA-DRβ1*0101, HLA-DRβ1*0301, HLA-DRβ1*0401, and HLA-DRβ1*0701 and is stimulatory for T cells restricted to complexes of SEQ ID NO: 2 and any one of said MHC Class II molecules, and an adjuvant.