THE USE OF THE GM1 MONOSIALOGANGLIOSIDE AND OF ITS INTERNAL ESTER DERIVATIVE TO PREVENT THE INSURGENCE IN MAN OF THE TOLERANCE TO THE ANALGESIC EFFECT OF MORPHINE AND ANALOGUES

摘要

A new use of monosialoganglioside GM1 of its pharmacologically acceptable salts and of its internal ester derivative for the preparation of pharmaceutical compositions apt to prevent the insurgence in man of the tolerance to the analgesic effect of morphine, of chemically correlated opiates, of methadone and its derivatives is described.