METHOD AND APPARATUS FOR PREPARING BI-213 FOR HUMAN THERAPEUTIC USE

摘要

This invention relates to a method and an apparatus for preparing Bi-213 to be integrated in a radioimmunoconjugate for human therapeutic use. According to the invention the method comprises the sequence of steps as follows: a) an ampoule (5) containing colloid-free actinium-225, obtained from drying an actinium nitrate solution, is loaded into a container (20) provided with radiation panels (21); b) a dissolving medium is poured into the ampoule (5); c) the solution obtained in the ampoule is transferred into an ion exchange column (6); d) an elution medium is circulated through the column (6); e) the eluate containing eluted Bi-213 is pumped towards a vial (10) for quantification and quality control.