摘要 |
The present invention provides compounds of formula (V) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof
wherein
R
is aryl or heteroaryl, each of which may be substituted by 1 to 4 groups J selected from:
halogen, C1-C6 alkyl, C1-C6 alkoxy, halo C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo C1-C6 alkoxy, -C(O)R 2 , nitro, hydroxy, -NR 3 R 4 , cyano, and a group Z;
R 1
is hydrogen, C3-C7 cycloalkyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo C1-C6 alkyl, halo C1-C6 alkoxy, halogen, NR 3 R 4 or cyano;
R 2
is a C1-C4 alkyl, -OR 3 or -NR 3 R 4 ;
R 3
is hydrogen or C1-C6 alkyl;
R 4
is hydrogen or C1-C6 alkyl;
R 5
is a C1-C6 alkyl, halo C1-C6 alkyl, C1-C6 alkoxy, halo C1-C6 alkoxy, C3-C7 cycloalkyl, hydroxy, halogen, nitro, cyano, -NR 3 R 4 , or -C(O)R 2 ;
R 6
is a C1-C6 alkyl, halo C1-C6 alkyl, C1-C6 alkoxy, halo C1-C6 alkoxy, C3-C7 cycloalkyl, hydroxy, halogen, nitro, cyano, -NR 3 R 4 , or -C(O)R 2 ;
R 7
is hydrogen, C1-C6 alkyl, halogen or halo C1-C6 alkyl;
R 8
is hydrogen, C3-C7 cycloalkyl, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, NR 3 R 4 or cyano;
Rg
is hydrogen, C3-C7 cycloalkyl, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, NR 3 R 4 or cyano;
R 10
is hydrogen, C3-C7 cycloalkyl, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, NR 3 R 4 or cyano;
R 11
is hydrogen, C3-C7 cycloalkyl, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, NR 3 R 4 or cyano;
R 12
is R 3 or -C(O)R 2 ;
D
is CR 8 R 9 or is CR 8 when double bonded with G;
G
is CR 10 R 11 or is CR 10 when double bonded with D;
Z
is a 5-6 membered heterocycle, which may be substituted by 1 to 8 R 5 groups; or a phenyl ring, which may be substituted by 1 to 4 R 5 groups;
m
is an integer from 0 to 2; and
q
is an integer from 0 to 4;
Y
is nitrogen or -CR 7 ;
to processes for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of conditions mediated by corticotropin-releasing factor (CRF). |