PROCESS FOR THE ETHERIFICATION OF AMINO ALCOHOLS WITH METAL ALCOHOLATES

摘要

Process for the etherification of amino alcohols with metal alcoholates;A process for the preparation of the ether of formula I;;where R1 and R2 independently from one another are hydrogen or an alkyl group with 1 to 10 C atoms, R3 is an alkyl group with 1 to 10 carbon atoms and;X is a bond or a hydrocarbon group with 1 to 10 carbon atoms;comprising;a) deprotonating the amino alcohol of formula II;;where R1, R2 and X have the meaning above;with a metal alcoholate as deprotonating agent to give the anion of formula III;;where R1, R2 and X have the meaning above;and;b) alkylation of the anion obtained in step a) with an alkylation agent to give the ether of formula I,;wherein the deprotonating agent in step a) is used in equimolar or less than equimolar amounts compared to the amino alcohol and;the alkylation agent in step b) is used in equimolar or less than equimolar amounts compared to the anion of formula III.

主权项

1. A process for the preparation of the ether of formula I where R1 and R2 independently from one another are hydrogen or an alkyl group with 1 to 10 C atoms, R3 is an alkyl group with 1 to 10 carbon atoms and X is a bond or a hydrocarbon group with 1 to 10 carbon atoms comprisinga) deprotonating the amino alcohol of formula II where R1, R2 and X have the meaning above with a metal alcoholate as deprotonating agent to give the anion of formula III where R1, R2 and X have the meaning above and b) alkylation of the anion obtained in step a) with an alkylation agent to give the ether of formula I, wherein the deprotonating agent in step a) is used in equimolar or less than equimolar amounts compared to the amino alcohol and the alkylation agent in step b) is used in equimolar or less than equimolar amounts compared to the anion of formula III.