| 发明名称 |
METHODS FOR USE OF SMALL MOLECULE ACTIVATORS OF HEM-Y / PROTOPORPHYRINOGEN OXIDASE (PPO) |
| 摘要 |
A method for treating a microbial infection involves administering an effective amount of a compound of the formula:;;wherein R1 is H, alkyl, aryl, heteroaryl, R2 is H, halogen, alkyl, aryl, heteroaryl, R3 is H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, R4 is H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, R5 is H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, R6 is H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, R7 is H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, R8 is —CR3, O, S, wherein R5 and R6, R7 and R6, R5 and R4, R4 and R3 can cyclize forming a 3-10 member ring comprising C, O, S, and/or N optionally substituted with one or more R3; and administering light therapy, such as a photodynamic therapy (PDT) light source. |
| 申请公布号 |
US2016213780(A1) |
申请公布日期 |
2016.07.28 |
| 申请号 |
US201615004141 |
申请日期 |
2016.01.22 |
| 申请人 |
Vanderbilt University |
发明人 |
Skaar Eric P.;Surdel Matthew;Sulikowski Gary A.;Dutter Brendan;Reid Paul;Waterson Alex |
| 分类号 |
A61K41/00;C12Q1/18;A61N5/06;C07D405/04;C07D409/04;C07D231/12;C12N9/02;C12Q1/68 |
主分类号 |
A61K41/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating a microbial infection, comprising:
administering an effective amount of a compound of the formula:wherein,
R1 is H, alkyl, aryl, heteroaryl; R2 is H, halogen, alkyl, aryl, heteroaryl; R3 is H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide; R4 is H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide; R5 is H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide; R6 is H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide; R7 is H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide; R8 is —CR3, O, S;wherein R5 and R6, R7 and R6, R5 and R4, R4 and R3 can cyclize forming a 3-10 member ring comprising C, O, S, and/or N optionally substituted with one or more R3; and
administering light therapy. |
| 地址 |
Nashville TN US |
