Closed Tip Dynamic Microvalve Protection Device

摘要

An endovascular microvalve device for use in a vessel during a therapy procedure includes an outer catheter, an inner catheter displaceable within the outer catheter, and a filter valve coupled to the distal ends of the inner and outer catheters. The valve is constructed of a braid of elongate first filaments coupled together at their proximal ends in a manner that the first filaments are movable relative to each other along their lengths. A filter is provided to the braid formed by electrostatically depositing or spinning polymeric second filaments onto the braided first filaments. The lumen of the inner catheter delivers a therapeutic agent beyond the valve. The device is used to provide a therapy in which a therapeutic agent is infused into an organ.

主权项

1. An endovascular microvalve device for temporary use in a vessel having a vessel wall during an intravascular procedure, comprising:
a) a flexible outer catheter having a proximal end and a distal end; b) a flexible inner catheter having a proximal end and a distal end with an orifice, the inner catheter extending through and longitudinally displaceable relative to the outer catheter; and c) a filter valve having a proximal end and distal end, the proximal end of the filter valve coupled to the distal end of the outer catheter, and the distal end of the filter valve coupled to the inner catheter adjacent the distal end of the inner catheter, such that longitudinal displacement of the inner catheter relative to the outer catheter moves the filter valve from a non-deployed configuration to a deployed configuration, the filter valve having a proximal portion comprising a braided filamentary structure and distal portion comprising a non-braided spirally wound filamentary structure, and the distal portion further comprising a porous polymeric material coupled to the spiral wound filamentary structure, the porous polymeric material defining a pore size not exceeding 500 μm.