LIPID A ANALOG/IMMUNOGENIC CARRIER CONJUGATES, THE USE THEREOF AS VACCINES AND POLYVALENT HYPERIMMUNE GAMMAGLOBULINS

摘要

The invention relates to lipid A analog/immunogenic carrier conjugates and the use thereof as vaccines for the prophylaxis of septic shock in animals. The invention provides for a polyvalent vaccine which contains the lipid A analog/immunogenic carrier conjugate. The invention also relates to a polyvalent hyperimmune gammaglobulin comprising an effective neutralizing amount of an anti-lipid A gammaglobulin and an effective opsonizing amount of an O antigen specific gammaglobulin. Kits containing these materials are also provided.