摘要 |
<p>An estradiol derivative-chlorambucil conjugate of the formula (I): <CHEM> wherein R<1> is alkyl or alkoxyl of 1 to 4 carbon atoms; R<2> is acyl, dansyl, or alkyl; R<3>, R<4>, and R<5> independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an integer of 0 to 3; provided that when n is 0, all of R<3>, R<4>, and R<5> are not H at the same time, and at least one of R<3>, R<4>, and R<5> is a group other than H and OH; and further, when n is 2 or 3, the groups R<1> are the same or different; a process for preparing the same, and a pharmaceutical composition containing the conjugate are described.</p> |
申请人 |
KUREHA CHEMICAL INDUSTRY CO., LTD. |
发明人 |
TAMURA, FUMIO;SAITO, TSUYOSHI;MITSUHASHI, SATOSHI, RAIONZU-MANSHON;MATSUDAIRA, TADAHIRO;ASANO, KIRO |