HIGH-DENSITY ION TRANSPORT MEASUREMENT BIOCHIP DEVICES AND METHODS

摘要

The present invention includes biochips for the measurement of cellular ion channels and methods of use and manufacture. The biochips of the present invention have enhanced sealing capabilities provided in part by chemically modifying the surface of the biochip surface or substrate or by exposure to an ionized gas. The present invention also includes novel cartridges for biochips.

主权项

1. An ion channel chip comprising:
a. a planar polymer plastic substrate treated with an ionized gas; b. at least one aperture positioned substantially perpendicular to said planar polymer plastic substrate; c. a gasket positioned about said aperture defining the perimeter of a chamber, and wherein said treatment forms at least one functional group or moiety positioned sufficiently close to said aperture such that a cell can simultaneously contact said at least one functional group or moiety and said aperture.