Fused benzo compounds containing a nitrogen heterocycle for the treatment of central nervous system disorders

摘要

Fused benzo compounds of formula I are provided, wherein A is a 2 to 6 membered hydrocarbon spacer group, B is a polar divalent group selected from a group (a); U is C, N or CH; X is a divalent 3-4 membered chain optionally comprising one or more heteroatoms; R1 is an aliphatic hydrocarbon group, arylalkyl or diphenylalkyl; R2 and R3 are hydrogen or alkyl or together form an ethylene or propylene bridge; R4, R5 and R6 are hydrogen or substituents; R7 and R8 are hydrogen or substituents including -COOR9 and -CONR10R11; are 5-HT1A receptor ligands useful in the treatment of CNS disorders. Pharmaceutical compositions comprising the compounds and their use for the manufacture of a pharmaceutical preparation are also provided./!