发明名称 |
TREATMENT OF HUMAN PAPILLOMAVIRUS (HPV)-INFECTED CELLS |
摘要 |
This invention provides a novel gene therapy approach to specifically eliminate keratinocytes, or other cells, expressing early HPV (e.g. HPV 16) genes and which is minimally toxic to HPV-negative cells. In a preferred embodiment this method involves transfecting a mammalian cell with a nucleic acid construct encoding an HPV specific promoter that is induced by an HPV protein where the promoter is operably linked to a nucleic acid comprising a cytotoxic gene such that the cell, when infected with a human papilloma viru s induces expression of the cytotoxic gene thereby resulting in the death of said mammalian cell.
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申请公布号 |
CA2408830(A1) |
申请公布日期 |
2001.11.22 |
申请号 |
CA20012408830 |
申请日期 |
2001.05.11 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
SETHI, NEERJA;PALEFSKY, JOEL |
分类号 |
C12N15/09;A61K31/522;A61K35/76;A61K39/12;A61K48/00;A61P11/04;A61P15/00;A61P17/00;A61P35/00;A61P35/04;C12N5/10;C12N15/85;C12Q1/70;(IPC1-7):A61K48/00;C12N15/86 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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