发明名称 |
PHOSPHOLIPID SCRAMBLASE 3 |
摘要 |
Phospholipid scramblase 3 (PLS3) is a newly recognized member of a family of proteins responsible for phospholipid translocation between two lipid compartments. A novel isoform of PLS3 is identified and characterized herein . The function of PLS3 in mitochondira was disrupted, yielding an inactive mutant PLS3(F258V). Cells transfected with PLS3(F258V) exhibited reduced proliferative capacity that was unaffected by the presence of Na3N. PLS3(F258V)-expressing cells exhibit abnormal mitochondrial metabolism and structure and were associated with decreased sensitivity to UV-and tBid- induced apoptosis, and diminished translocation of cardiolipin to the outer mitochondrial membrane. Cells transfected with wild-type PLS3 displayed increased sensitivity to apoptosis and enhanced cardiolipin translocation. These studies identify PLS3 as a regulator of mitochondrial structure and respiration, and cardiolipin transport in apoptosis.
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申请公布号 |
CA2518876(A1) |
申请公布日期 |
2004.09.23 |
申请号 |
CA20042518876 |
申请日期 |
2004.03.15 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
LIU, JIHUA;CHEN, JUN;LEE, RUEY-MIN;DAI, QIANG |
分类号 |
C07K14/47;(IPC1-7):A61K48/00;C07H21/02;C07H21/04;C12N15/63;C12Q1/68 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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