TRANS-DECAHYDROISOQUINOLINE DERIVATIVES

摘要

The invention relates to antibacterial compounds of formula (I) wherein R1 is alkoxy, one or two of U, V, W, X represent(s) N, the remaining represents CH, whereby V may also represent CRa, W may also represent CRb and X may also represent CRC, Ra is hydroxyalkyl; Rb is alkoxycarbonyl, carboxy or hydroxyalkyl; Rc is halogen, R2is alkoxycarbonyl, carboxy, hydroxyalkyl or aminoalkyl, A is CH2B, C(=O)B or CH2CH=CHD, B is the group (II) wherein Z is N or CH and the ring P is selected from the formula (III) in which Q is O or S, and D is aryl (e.g. 1,4-difluoro-2 -phenyl).