PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF PARKINSON'S DISEASE AND RELATED DISORDERS

摘要

The invention relates to the improvement in the treatment of certain neural disorders / diseases, such as Parkinson's disease and other motor disorders. The invention relates to drug compositions and dosage forms comprising said drug composition; methods of manufacturing the drug compositions and dosage forms; and methods of treatment, comprising administering the drug composition and dosage form to an individual. In certain embodiments, a decarboxylase enzyme inhibitor (e.g., carbidopa) extended release formulation is formulated with one or more bioadhesive polymers which may be useful for preferentially targeting the release of the decarboxylase enzyme inhibitor at the target absorption site. Upon administration to the patient, the inhibitor is delivered to a desired tissue location (e.g., proximal small intestine), and is released over an extended period (preferably from after dinner to the morning after).