发明名称 |
PHARMACEUTICAL FORMULATION WITH AN INSOLUBLE ACTIVE AGENT FOR PULMONARY ADMINISTRATION |
摘要 |
A pharmaceutical formulation for pulmonary administration comprises particulates comprising an active agent particle in a lipid matrix, the active agent having a solubility in water of less than 1.0 mg/ml. In one version, at least 90% of the active agent particles in the pharmaceutical formulation have a geometric diameter less than 3 mum. In another version, the insoluble active agent comprises amphotericin B. The particulates may have a size and shape to allow the aerosolized pharmaceutical formulation to be delivered to the deep lung. |
申请公布号 |
EP1589947(B1) |
申请公布日期 |
2016.06.15 |
申请号 |
EP20030800395 |
申请日期 |
2003.12.31 |
申请人 |
NOVARTIS AG |
发明人 |
TARARA, THOMAS, E.;WEERS, JEFFRY, G. |
分类号 |
A61K9/16;A61K9/00;A61K31/7048 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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