Anti-human IL-23 receptor antibody and encoding polynucleotides

摘要

[Problem];An object of the present invention is to provide an anti-human IL-23R antibody having excellent activity and/or cross-reactivity compared to conventional IL-23R antibodies, and means for using the antibody to prevent or treat various diseases such as ophthalmic disease, inflammatory bowel disease, or psoriasis in which human IL-23R is involved in pathogenesis.;[Means for Solution];An anti-human IL-23R antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:10 or 14 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:6 or 18.

主权项

1. An anti-human interleukin-23 receptor (IL-23R) antibody or an anti-human IL-23R antibody fragment selected from any one of the following (a) to (d):
(a) an anti-human IL-23R antibody or an anti-human IL-23R antibody fragment comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:10 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:18; (b) an anti-human IL-23R antibody or an anti-human IL-23R antibody fragment comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:10 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:6; (c) an anti-human IL-23R antibody or an anti-human IL-23R antibody fragment comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:14 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:6; and (d) an anti-human IL-23R antibody or an anti-human IL-23R antibody fragment comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:14 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:18.