| 发明名称 | Extended recombinant polypeptides and compositions comprising same | ||
| 摘要 | The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions. | ||
| 申请公布号 | US9371369(B2) | 申请公布日期 | 2016.06.21 |
| 申请号 | US201414168973 | 申请日期 | 2014.01.30 |
| 申请人 | Amunix Operating Inc. | 发明人 | Schellenberger Volker;Silverman Joshua;Wang Chia-Wei;Spink Benjamin;Stemmer Willem P.;Geething Nathan;To Wayne;Cleland Jeffrey L. |
| 分类号 | A61K38/16;A61K38/18;C07K14/61;C07K14/46;C07K14/545;C07K14/00;C07K14/605;C07K14/745;C07K14/47 | 主分类号 | A61K38/16 |
| 代理机构 | Wilson Sonsini Goodrich & Rosati | 代理人 | Wilson Sonsini Goodrich & Rosati |
| 主权项 | 1. An isolated extended recombinant polypeptide (XTEN) comprising an amino acid sequence which has at least 90% sequence identity to a sequence selected from the group consisting of SEQ ID NOS: 204, 206, 210, 213, 216-219, 373-409, 684-698, 700-716, 762-769, 771, 774, and 777-780 wherein the XTEN comprises a motif selected from the group consisting of SEQ ID NO: 186, SEQ ID NO: 187, SEQ ID NO: 188, and SEQ ID NO: 189. | ||
| 地址 | Mountain View CA US | ||