| 发明名称 | Methods of promoting CNS neuronal repair by inhibiting LRP-1 | ||
| 摘要 | This invention provides methods for promoting and/or restoring neurite outgrowth and neuronal regeneration by contacting an injured neuron with an inhibitor of low density lipoprotein receptor-related protein-1 (LRP-1). | ||
| 申请公布号 | US9376481(B2) | 申请公布日期 | 2016.06.28 |
| 申请号 | US201214113626 | 申请日期 | 2012.04.26 |
| 申请人 | The Regents of the University of California;J. David Gladsone Institutes | 发明人 | Gonias Steven L.;Stiles Travis;Gaultier Alban;Campana Wendy M.;Akassoglou Katerina |
| 分类号 | C07K14/705;A61K38/17;A61K38/18;A61K45/06;C07K16/28;C12N15/113;C12N15/86 | 主分类号 | C07K14/705 |
| 代理机构 | Wagenknecht IP Law Group PC | 代理人 | Wagenknecht IP Law Group PC |
| 主权项 | 1. A method of enhancing nerve growth or neuronal regeneration, comprising contacting a neuron with an inhibitor of low density lipoprotein receptor-related protein-1 (LRP-1) activity in the presence of a myelin-associated inhibitory protein, wherein the inhibitor of LRP-1 activity is receptor associated protein (RAP). | ||
| 地址 | Oakland CA US | ||