| 摘要 |
<p>A known surface adhesin (NadA) in Neisseria meningitidis contains sequenceswhich correspond to the fusion peptide, HR1 repeat and HR2 repeat seen in the envelopeprotein of viruses.Fusion inhibitors may thus be used to inhibit meningococcalinfection, and the invention provides a compound that can bind to the heptad repeatsequence(s) HR1 and/or HR2 of the NadA adhesin on the surface of a meningococcus,thereby inhibiting the ability of the meningococcus either to infect a host organismor to spread an existing infection.</p> |
