发明名称 |
PHARMACEUTICAL COMPOSITIONS COMPRISING MODIFIED CNS-DERIVED PEPTIDES FOR PROMOTING NERVE REGENERATION AND PREVENTION OF NERVE DEGENERATION |
摘要 |
Compositions are provided for promoting nerve regeneration or reducing or inhibiting degeneration in the CNS or PNS to ameliorate the effects of injur y or disease, comprising an active ingredient selected from: (a) a peptide obtained by modification of a self-peptide derived from a CNS-specific antigen, which modification consists in the replacement of one or more amino acid residues of the self-peptide by different amino acid residues, said modified CNS peptide still being capable of recognizing the T-cell receptor recognized by the self-peptide but with less affinity; (b) a nucleotide sequence encoding said peptide; (c) T cells activated by said peptide; and ( d) any combination of (a) - (c). The peptide is preferably obtained by modification of the self-peptide p87-99 of MBP, more preferably, by replacin g lysine 91 with glycine (G91) or alanine (A91) or by replacing proline 96 wit h alanine (A96).
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申请公布号 |
CA2434567(A1) |
申请公布日期 |
2002.07.18 |
申请号 |
CA20022434567 |
申请日期 |
2002.01.14 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD. |
发明人 |
HAUBEN, EHUD;EISENBACH-SCHWARTZ, MICHAL |
分类号 |
A61K48/00;A61K;A61K6/00;A61K31/7088;A61K35/14;A61K35/26;A61K38/00;A61K38/17;A61K38/39;A61K38/48;A61K39/00;A61P3/00;A61P9/10;A61P17/02;A61P25/00;A61P25/02;A61P25/14;A61P25/16;A61P25/28;A61P27/06;C07H21/04;C07K;C07K5/00;C07K14/00;C12N5/02;C12N5/08;C12N15/12;(IPC1-7):A61K48/00;A61K31/708 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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