发明名称 |
METHODS OF PURIFYING BISPECIFIC ANTIBODIES |
摘要 |
The invention relates to the purification of bispecific antibodies carrying a different specificity for each binding site of the immunoglobulin molecule from a mixture of monospecific antibodies. The bispecific antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other a Lambda constant domain. This invention in particular relates to the isolation of these bispecific antibodies from mixtures that contain monospecific antibodies having two Kappa light chains or portions thereof and monospecific antibodies having two Lambda light chains or portions thereof. The invention also provides the methods of efficiently purifying these bispecific antibodies. |
申请公布号 |
WO2016146594(A1) |
申请公布日期 |
2016.09.22 |
申请号 |
WO2016EP55474 |
申请日期 |
2016.03.14 |
申请人 |
NOVIMMUNE SA |
发明人 |
FOUQUE, Nicolas;DEPOISIER, Jean François;WILSON, Keith;VAJDA, Judith;MÜLLER, Egbert;DABRE, Romain |
分类号 |
C07K16/00;C07K16/24;C07K16/28;C07K16/46 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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