Self-assembled bivalent ligand complex (SABLC) libraries and methods for screening such libraries.

摘要

The present invention relates to identifying bivalent ligands binding to a target molecule, more particularly to self-assembled bivalent ligands comprising at least two separate ligands or two sub-libraries thereof, each ligand covalently attached via an optional spacer molecule to the ends of a nucleic acid sequence. The said ligands dimerise via the nucleic sequence and are subsequently covalently linked. The bivalent ligands (or monomeric ligands) are provided as libraries and are screened for a specific binding interaction with a target molecule (e.g. a biological target). Bivalent ligands are identified by unique sequence identifier sequences that are comprised in the nucleic acid sequences.