发明名称 |
ALVOCIDIB PRODRUGS HAVING INCREASED BIOAVAILABILITY |
摘要 |
Compounds having the following structure (I): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein one of R1, R2 or R3 is -P(=O)(OH)2, and the other two of R1, R2 and R3 are each H, are provided. Pharmaceutical compositions comprising the compounds, and methods for use of the compounds for treating diseases associated with overexpression of a cyclin-dependent kinase (CDK) are also provided. |
申请公布号 |
WO2016187316(A1) |
申请公布日期 |
2016.11.24 |
申请号 |
WO2016US33099 |
申请日期 |
2016.05.18 |
申请人 |
TOLERO PHARMACEUTICALS, INC. |
发明人 |
SIDDIQUI-JAIN, Adam;BEARSS, David, J. |
分类号 |
C07F9/12;A61K31/661;A61P35/00 |
主分类号 |
C07F9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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