| 摘要 |
PURPOSE:To obtain a novel fused protein which can manifest sufficiently physiological activity through the biotechnology techniques, by introducing a physiologically active peptide such as a cancer metastasis inhibitory protein into the polypeptide chains of human serum albumen in one or more desired positions. CONSTITUTION:A peptide having the amino acid sequence represented by the formula and a physiological activity such as cancer metastasis inhibitory peptide is introduced into at least one selected from the amino terminus, the carboxyl terminus, between the first and the second domains or between the second and the third domains or their combinations. This fused protein is produced by ligating the gene coding the peptide having a physiological activity such as a cancer metastasis inhibitory protein to the gene coding the human serum albumen to prepare a gene for coding the fused protein, then, incorporting the gene into the expression vector and introducing the vector into the host cells such as of Schizosaccharomyces pombe for expression. |
