发明名称 |
Uses for DNA structure-specific recognition protein |
摘要 |
Methods disclosed herein capitalize on the ability of DNA Structure Specific Recognition Proteins (SSRPs) to bind to genomic lesions formed by chemotherapeutic agents, particularly cisplatin-type agents. Methods are provided for predicting whether an agent that damages DNA will also be cytotoxic, and for predicting whether particular eukaryotic cells will be susceptible to killing by a genotoxic drug. A screening method is provided for identifying new genotoxic drugs that produce SSRP-recognized lesions in DNA. Methods also are provided for sensitizing particular eukaryotic cells to killing by chemotherapeutic agents, particularly cisplatin-type drugs.
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申请公布号 |
US6475791(B1) |
申请公布日期 |
2002.11.05 |
申请号 |
US19970866840 |
申请日期 |
1997.06.02 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
LIPPARD STEPHEN J.;ESSIGMANN JOHN M.;DONAHUE BRIAN A.;TONEY JEFFREY H.;BRUHN SUZANNE L.;PIL PIETER M.;BROWN STEVEN J.;KELLETT PATTI J. |
分类号 |
A61K38/00;C07K14/435;C07K14/47;C07K16/18;C12Q1/68;(IPC1-7):A61K48/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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