METHOD OF EVALUATING HUMAN DENDRITIC CELLS AND HUMAN CELL IMMUNOTHERAPEUTIC AGENT

摘要

It is intended to provide a method of evaluating the antigen-presenting ability of human dendritic cells which comprises the following steps; (1) the step of administering human dendritic cells pulsed with a-galactosylceramide to a nonhuman mammal; (2) the step of collecting an NKT cell-containing sample from the nonhuman mammal; and (3) the step of detecting the activation of the NKT cells present in the sample. It is also intended to provide a human NKT cell immunotherapeutic agent containing human dendritic cells which have been evaluated by the above method as having an antigen-presenting ability to NKT cells.