NEUTROKINE .ALPHA.

摘要

The present invention relates to a novel Neutrokine .alpha. protein which is a member of the TNF protein family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine .alpha. protein includi ng soluble forms of the extracellular domain. Neutrokine .alpha. polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine .alpha. activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.