| 发明名称 | Adsorptive membranes for trapping viruses | ||
| 摘要 | A disposable, virus-trapping membrane, and a corresponding method to remove viruses from solution are described. The membrane includes a disposable, micro-porous filter membrane and a ligand immobilized on the membrane. The ligand irreversibly and selectively binds viruses. The ligand also has a pKa sufficiently high to repel antibodies via electrostatic charge repulsion. | ||
| 申请公布号 | US9375499(B2) | 申请公布日期 | 2016.06.28 |
| 申请号 | US200711776774 | 申请日期 | 2007.07.12 |
| 申请人 | Wisconsin Alumni Research Foundation | 发明人 | Etzel Mark R. |
| 分类号 | C12Q1/70;A61L2/00;B01D61/14;B01D67/00;B01J20/28;B01J20/32;B01J20/26 | 主分类号 | C12Q1/70 |
| 代理机构 | DeWitt Ross & Stevens SC | 代理人 | Blasiole Daniel A.;Leone, Esq. Joseph T.;DeWitt Ross & Stevens SC |
| 主权项 | 1. A disposable, virus-trapping membrane comprising: a disposable, micro-porous filter membrane; and a multi-modal anion-exchange ligand immobilized on the membrane, wherein the ligand is dimensioned and configured to: (a) bind neutral viruses;(b) have a pKa sufficiently high to repel basic proteins via electrostatic charge repulsion; and(c) yield a log-reduction value (LRV) of at least 1.0 for the neutral viruses disposed in a solution comprising 50 mM salt. | ||
| 地址 | Madison WI US | ||