发明名称 |
ATTENUATED VACCINES TO PROTECT AGAINST TICK-BORNE EHRLICHIA SPECIES INFECTIONS |
摘要 |
Attenuated vaccines to protect vertebrate animals and people against tick-born rickettsial, Ehrlichia and Anaplasma species infections is disclosed. Also disclosed are methods to modify the organism to achieve the desired immunity through the modification of a novel genetic region involved in pathogenesis. These compounds represent a needed vaccine against an organism causing life-threatening febrile illness in humans and animals, and also represent the potential to develop new classes of drugs targeting the gene products of genes Ech_0660, Ech_0379, and Ech_0230, and their homologs of other related rickettsial pathogens. |
申请公布号 |
WO2016118512(A1) |
申请公布日期 |
2016.07.28 |
申请号 |
WO2016US13933 |
申请日期 |
2016.01.19 |
申请人 |
KANSAS STATE UNIVERSITY RESEARCH FOUNDATION |
发明人 |
GANTA, ROMAN R.;CHENG, CHUANMIN;NAIR, ARATHY D. S.;JAWORSKI, DEBORAH;GANTA, SUHASINI |
分类号 |
A61K39/02 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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