| 发明名称 |
INHIBITORS OF INFLUENZA VIRUSES REPLICATION |
| 摘要 |
Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula:;;are Form A of HCl salt of Compound (1).½H2O, Form F of HCl salt of Compound (1).3H2O, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). Such polymorphic forms are employed for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject. |
| 申请公布号 |
US2016251353(A1) |
申请公布日期 |
2016.09.01 |
| 申请号 |
US201615150459 |
申请日期 |
2016.05.10 |
| 申请人 |
Vertex Pharmaceuticals Incorporated |
发明人 |
Nti-Addae Kwame W.;Waldo Michael;O'Neil Simon Adam;Van Alsten John Gregg;Macikenas Dainius;Mudunuri Praveen;Shi Yi;Ledeboer Mark Willem;Jurkauskas Valdas;Medek Ales;Jones Steven;Byrn Randal;Asmal Mohammed;Robertson Sarah Marie;Tsai Wanjung |
| 分类号 |
C07D471/04;A61K45/06;A61K31/4965;A61K31/16;A61K31/351;A61K31/506;C07C309/30 |
主分类号 |
C07D471/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polymorphic form of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula:and wherein the polymorphic form is selected from the group consisting of:
Form A of HCl salt of Compound (1).½H2O, Form F of HCl salt of Compound (1).3H2O, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). |
| 地址 |
Boston MA US |
