SYNERGISTIC COMBINATION OF A PHYLLANTHUS AMARUS EXTRACT AND 5-FLUOROURACIL FOR TREATMENT OF SUBJECTS WITH CANCER

摘要

The present invention relates in a first aspect to a method for treating a subject suffering from cancer, in particular liver cancer. The method comprises administrating synergistic amounts of a Phyllanthus amarus extract and 5-fluorouracil or a prodrug 5 thereof to a subject, in particular a human. In another aspect of the present invention, a method of potentiating the activity of 5-fluorouracil in cancer cells is provided. In a further aspect, the present invention provides a kit comprising the Phyllanthus amarus extract and the 5-fluorouracil or a prodrug thereof. It has been found that the combination treatment with the Phyllanthus amarus extract 10 of the present invention and 5-fluorouracil or a prodrug thereof allows for synergistically potentiating the activity of 5-fluorouracil. Combined administration of Phyllanthus amarus and 5-fluorouracil or a prodrug thereof, thus, represents a highly promising treatment option for treating patients with cancer with enhanced anti-cancer activity of 5-fluorouracil while reducing or preventing resistances.