Coated particles for sustained-release pharmaceutical administration

摘要

Coated microparticles for sustained-release of an active pharmaceutical ingredient after parenteral administration, and methods of producing such coated microparticles, are provided. The coated microparticles comprise core particles of an active pharmaceutical ingredient and a first polymeric coating on the core particles. The first polymeric coating is permeable to the active pharmaceutical ingredient forms a saturated solution within the coated microparticle, resulting in pseudo-zero-sustained release period. A second polymeric coating can be employed to add mechanical support or as a rate-controlling element.

主权项

1. A pharmaceutical preparation for sustained-release of an active pharmaceutical ingredient after parenteral administration comprising:
a multiplicity of coated microparticles, said coated microparticles having a mean dimension of less than 1 mm and each coated microparticle comprising (a) a core particle consisting of said active pharmaceutical ingredient; and (b) a first polymeric coating enveloping said core particle; wherein said first polymeric coating is crystalline and is permeable to water and said active pharmaceutical ingredient while maintaining structure integrity during a sustained-release period from administration of said microparticles.