Filamentary devices for treatment of vascular defects

摘要

Methods for treatment of a cerebral aneurysm are described. Methods include providing a self-expanding permeable shell having a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a globular and longitudinally shortened configuration relative to the radially constrained state, and a plurality of elongate filaments that are woven together, which define a cavity of the permeable shell. The permeable shell includes composite filaments. The composite filaments may have a diameter of 0.00075″, 0.001″, 0.0015″, and/or 0.00125″. The permeable shell is advanced in the constrained state within a catheter. The permeable shell is then deploying the permeable shell within the cerebral aneurysm, wherein the permeable shell expands to the expanded state within the cerebral aneurysm. The catheter is then withdrawn after deploying the permeable shell.

主权项

1. A method for treating a cerebral aneurysm, comprising the steps of:
providing a resilient self-expanding permeable shell, the permeable shell having to distal end and a proximal end and including a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a globular and longitudinally shortened configuration relative to the radially constrained state, and a plurality of elongate filaments which are woven together and define a cavity of the permeable shell, the permeable shell comprising at least some composite filaments, the composite filaments comprising drawn filled tube wires comprising an external nitinol tube and a highly radiopaque material concentrically disposed within the external nitinol tube, wherein the permeable shell has at least about 40% composite filaments relative to a total number of filaments, and wherein a total number of filaments is about 70 to about 300, and wherein each of the composite filaments has a diameter selected from the group consisting of 0.00075″, 0.001″, 0.0015″, and 0.00125″; advancing the permeable shell in the radially constrained state within a catheter to a region of interest within a cerebral artery; deploying the permeable shell within the cerebral aneurysm, wherein the permeable shell expands to the expanded state within the cerebral aneurysm; and withdrawing the catheter from the region of interest after deploying the permeable shell, wherein the permeable shell is in the expanded state with the globular configuration after the catheter is withdrawn.