Optical resolution methods for bicyclic compounds using enzymes

摘要

An object of the present invention is to efficiently produce an optically active bicyclic compound. The optically active bicyclic compound is efficiently produced using an enzyme.

主权项

1. A method of producing a compound of formula (I): comprising: (1) allowing a racemic mixture of the compound of formula (I) and a compound of formula (II)  to react in the presence of:
a reductase or an alcohol dehydrogenase,a coenzyme, anda compound selected from formic acid, a salt of formic acid, glucose and a combination of the foregoing, in a buffer solution to convert the compound of formula (II) to a compound of formula (II′): wherein R1 is an ethyl group, and (2) separating the compound of formula (I) from the compound of formula (II′) to produce the compound of formula (I).