发明名称 |
POLYVALENT CONJUGATE VACCINE FOR CANCER |
摘要 |
This invention provides a polyvalent vaccine comprising at least two conjugated antigens selected from a group containing glycolipid antigen, polysaccharide antigen, mucin antigen, glycosylated mucin antigen and an appropriate adjuvant. This invention also provides a multivalent vaccine comprising at least two of the following: glycosylated MUC-1-32mer, Globo H, GM2, Ley, Tn(c), sTN(c), and TF(c). This invention provides the vaccine above, wherein the adjuvant is saponin-based adjuvant. This invention provides a method for inducing immune response in a subject comprising administering an effective amount of the vaccine above to the subject. Finally, this invention provides a method for treating cancer in a subject comprising administering an appropriate amount of the vaccine above to the subject. |
申请公布号 |
US2016250306(A1) |
申请公布日期 |
2016.09.01 |
申请号 |
US201514872232 |
申请日期 |
2015.10.01 |
申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
Livingston Philip O.;Ragupathi Govindaswami;Danishefsky Samuel J. |
分类号 |
A61K39/00;A61K39/385;A61K47/48 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
1. A polyvalent vaccine comprising at least two conjugated antigens selected from a group containing glycolipid antigen, polysaccharide antigen, mucin antigen, glycosylated mucin antigen and an appropriate adjuvant. |
地址 |
New York NY US |