发明名称 |
Antibodies Directed Against ICOS and Uses Thereof |
摘要 |
The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFNγ production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg. |
申请公布号 |
US2016264666(A1) |
申请公布日期 |
2016.09.15 |
申请号 |
US201615165152 |
申请日期 |
2016.05.26 |
申请人 |
INSERM (Institut National de la Sante et de la Recherche Medicale) ;INSTITUT JEAN PAOLI & IRENE CALMETTES ;UNIVERSITE D'AIX-MARSEILLE ;Universite Claude Bernard - Lyon 1 ;Centre Leon Berard |
发明人 |
Faget Julien;Caux Christophe;Menetrier-Caux Christine;Nunes Jacques;Olive Daniel |
分类号 |
C07K16/28;G01N33/574 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Paris FR |