| 摘要 |
In general, among other things, compounds of Formula I are provided:;;in which R11 is selected from the group consisting of benzylamino, N-methylbenzylamino, morpholino, thiomorpholino, pyrrolidino, etc.; R13 is selected from the group consisting of 3-(1-ethanol-2-yl)phenyl, 3-(1-ol-2,2,2-trifluoroethan-2-yl)phenyl, 2-(1-ol-2,2,2-trifluoroethan-2-yl)phenyl, etc.; and R12 and R14 are each independently hydrogen or alkyl. Methods of treatment are also provided. |
| 主权项 |
1. A compound of Formula I:or a pharmaceutically acceptable salt thereof, in which
R11 is selected from the group consisting of benzylamino, N-methylbenzylamino, N-methyl(4-fluorobenzyl)amino, N-methyl(4-methoxybenzyl)amino, N-methyl(3,5-dimethoxybenzyl)amino, N-methyl(pyridin-2-yl)amino, N-methyl(pyridin-3-yl)amino, piperidino, 4-methylpiperzin-1-yl, morpholino, thiomorpholino, pyrrolidino, 3-methylpyrrolidin-1-yl, 3-methoxypyrrolidin-1-yl, pyrrolidin-3-ol-1-yl, 2-(2-methanol-1-yl)pyrrolid-1-yl, 2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl, 2-(2-propanol-2-yl)pyrrolidin-1-yl, isoindolin-2-yl, 4-(pyrrolidin-1-yl)piperidin-1-yl, N,N-diethylamino, N-methyl-N-ethylamino, N-methyl-N-isopropylamino, N-methyl-N-cyclopropylamino, N-methyl-N-ethynylamino, N-(2-methoxyethyl)-N-methylamino, N-(thiazol-2-ylmethyl)-N-methylamino, azetidin-1-yl, 3-methyl-3-ol-azetidin-1-yl, 3-(ethanol-2-yl)azetidin-1-yl, 3-methoxyazetidin-1-yl, 3-hydroxyazetidin-1-yl, 3-ethoxyazetidin-1-yl, 3-isopropoxyazetidin-1-yl, 3-(2-propanol-2-yl)azetidin-1-yl, 3-(morpholinomethyl)azetidin-1-yl, 3-morpholinoazetidin-1-yl, 3-(pyyrolidin-1-yl)azetidin-1-yl, 3-(pyrrolidin-1-ylmethyl)azetidin-1-yl, 3-(1-methoxyethyl)azetidin-1-yl, N-(3-(N,N-dimethylamino)propyl)-N-methylamino, and 4-(N,N-dimethylamino)piperidin-1-yl; R13 is selected from the group consisting of 3-(1-ethanol-2-yl)phenyl, 3-(1-ol-2,2,2-trifluoroethan-2-yl)phenyl, 2-(1-ol-2,2,2-trifluoroethan-2-yl)phenyl, 4-(1-ol-2,2,2-trifluoroethan-2-yl)phenyl, 3-(3-ol-oxetan-3-yl)phenyl, 3-methanonylphenyl, 3-((piperazin-1-yl)methanon-2-yl)phenyl, 3-((morpholin-1-yl)methanon-2-yl)phenyl, 3-((pyrrolidin-1-yl)methanon-2-yl)phenyl, 3-((N-cyclopropyl)amid-2-yl)phenyl, methanonyl, trifluoromethanonyl, 1-ol-2,2,2-trifluoroethan-2-yl, 3-ol-oxetan-3-yl, (1-ol-2,2,2-trifluoroethan-2-yl)thiophen-2-yl, 1-ol-prop-2-en-3-yl, 2-ol-but-3-en-4-yl, and 2-ol-2-trifluoromethyl-(1,1,1-trifluoro)but-3-en-4-yl; and R12 and R14 are each independently hydrogen or alkyl. |
