METHODS FOR PREDICTING TIME-TO-DELIVERY IN PREGNANT WOMEN

摘要

The present disclosure relates to methods for predicting time-to-delivery in pregnant women. The methods include predicting that a pregnant woman will deliver within a predetermined time frame if PAMG-1 is determined to be present at a level above a predetermined detection threshold in a vaginal fluid sample obtained from the pregnant woman. Also provided are methods for determining a patient's risk of preterm labor and/or spontaneous rupture of the chorioamniotic membrane.

主权项

1. A method of predicting time to delivery (TTD), the method comprising:
(a) contacting a vaginal fluid sample obtained from a pregnant woman with at least two PAMG-1-specific monoclonal antibodies, wherein at least one of the antibodies binds to PAMG-1 when present in the sample to form a PAMG-1/monoclonal antibody complex; (b) detecting the presence of the PAMG-1/monoclonal antibody complex in the sample only when the concentration of PAMG-1 in the sample exceeds a predefined detection threshold; and (c) predicting that the pregnant woman will deliver within a predetermined time frame if PAMG-1 is detected; or (d) predicting that the pregnant woman will not deliver within the predetermined time frame if PAMG-1 is not detected.