发明名称 |
Prostate kallikrein allergen |
摘要 |
Methods for treatment of a Type I allergy in a mammal comprise administering to an individual in need of such treatment a polypeptide of SEQ ID NO: 1 or the mature protein, amino acids 25-260, of the polypeptide of SEQ ID NO: 1, or a fragment of the polypeptide or the mature protein, which fragment shares epitopes for antibodies with the polypeptide or the mature protein, respectively, or a hypoallergenic form thereof that is modified to abrogate or attenuate its IgE binding response. Diagnostic kits comprise the polypeptide of SEQ ID NO: 1 or the mature protein, amino acids 25-260, of the polypeptide of SEQ ID NO: 1, immobilized on a solid support. |
申请公布号 |
US9518987(B2) |
申请公布日期 |
2016.12.13 |
申请号 |
US201514930737 |
申请日期 |
2015.11.03 |
申请人 |
PHADIA AB |
发明人 |
Mattsson Lars;Lidholm Jonas;Everberg Henrik |
分类号 |
A61K39/00;A61K38/00;A61K39/395;C07K1/00;C07K2/00;C07K4/00;C07K5/00;C07K7/00;C07K14/00;C07K16/00;C07K17/00;G01N33/53;G01N33/573;A61K39/35;C07K16/18;G01N33/68 |
主分类号 |
A61K39/00 |
代理机构 |
Porter Wright Morris & Arthur LLC |
代理人 |
Porter Wright Morris & Arthur LLC |
主权项 |
1. A method for treatment of a Type I allergy in a mammal, comprising administering to an individual in need of such treatment a polypeptide of SEQ ID NO: 1 or the mature protein, amino acids 25-260, of the polypeptide of SEQ ID NO: 1, or a fragment of the polypeptide or the mature protein, which fragment shares epitopes for antibodies with the polypeptide or the mature protein, respectively. |
地址 |
Uppsala SE |