| 摘要 |
An ascofuranone derivative represented by general formula (II) (wherein R<1> represents lower alkylcarbonyl, pyridylcarbonyl, benzoyl substituted by one lower alkyl or alkoxy group, toluenesulfonyl, carbamoyl substituted by one or two lower alkyl groups, or lower alkyl substituted by lower alkoxycarbonyl); a hypolipidemic agent containing the same as the active ingredient; and a hypoglycemic agent or a glycation inhibitor each containing an ascofuranone derivative represented by general formula (I) (wherein R represents hydrogen, lower alkylcarbonyl, pyridylcarbonyl, benzoyl substituted by one lower alkyl or alkoxy group, toluenesulfonyl, carbamoyl substituted by one or two lower alkyl groups, or lower alkyl substituted by lower alkoxycarbonyl) as the active ingredient. The compounds represented by the above general formulae (I) and (II) are excellent in hypoglycemic, hypolipidemic and glycation-inhibiting effects, thus being remarkably useful for preventing and treating diabetes, arteriosclerosis and so forth. |
