发明名称 |
Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use |
摘要 |
<p>Compounds of formula (I): <CHEM> wherein: R<1> is alkyl; R<2a>, R<2b>, R<2c> and R<2d> are the same or different and each is hydrogen, optionally substituted alkyl or various other organic groups; R<3> is alkyl; R<4> is a group of formula (II), (III), (IV), (V), (VI), (VII), (VIII) or (IX): <CHEM> wherein: A<1> is a single bond, alkylene or alkenylene; A<2> is or alkenylene; A<3> is a single bond, alkyleneor alkenylene; R<5a> and R<5b> are the same or different and each is hydrogen, alkyl or various other groups; R<6> is alkyl or phenyl; R<7> is hydrogen or alkyl; R<8> is alkyl or various other groups; and n is 0 or 1Ü and pharmaceutically acceptable salts thereof have valuable inhibitory activity against acyl-CoA: cholesterol acyl transferase.</p> |
申请公布号 |
EP0763524(A1) |
申请公布日期 |
1997.03.19 |
申请号 |
EP19960306781 |
申请日期 |
1996.09.18 |
申请人 |
SANKYO COMPANY LIMITED |
发明人 |
YOSHIDA, AKIRA;ODA, KOZO;KASAI, TAKASHI;SHIMADA, KOUSEI;KOGEN, HIROSHI;HAYAKAWA, ICHIRO;ISHIHARA, SADAO;KOGA, TEIICHIRO;KITAZAWA, EIICHI;TOKUI, TARO |
分类号 |
C07C275/28;A61K31/16;A61K31/445;A61K31/17;A61K31/18;A61K31/275;A61K31/40;A61K31/535;A61P9/10;C07C233/08;C07C235/38;C07C237/22;C07C237/42;C07C237/52;C07C251/48;C07C255/01;C07C255/44;C07C255/49;C07C255/57;C07C255/60;C07C259/10;C07C271/12;C07C271/20;C07C271/64;C07C275/24;C07C275/32;C07C275/34;C07C275/38;C07C275/40;C07C275/42;C07C311/04;C07C311/29;C07C311/32;C07C311/37;C07C311/46;C07C317/18;C07C317/46;C07C323/62;C07D207/02;C07D211/04;C07D213/56;C07D213/75;C07D213/81;C07D213/82;C07D213/88;C07D231/12;C07D231/40;C07D233/54;C07D239/28;C07D239/42;C07D241/20;C07D241/24;C07D265/28;C07D277/30;C07D277/46;C07D295/192;C07D295/215;C07D317/58;C07D317/60;C07D405/12;C07D521/00;(IPC1-7):C07C275/28;C07C233/55;C07C233/29 |
主分类号 |
C07C275/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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