发明名称 |
Process for the production of the dexfenfluramine hydrochloride |
摘要 |
<p>Process for the production of the anorexic drug dexfenfluramine hydrochloride (INN) which comprises the ethylation of the (S),(S)-N-(1-phenylethyl)- alpha -methyl-3-(trifluoromethyl)benzeneethanamine or of a salt thereof with an organic or inorganic acid, the debenzylation of the resulting intermediate (S),(S)-N-ethyl-N-(1-phenylethyl)- alpha -methyl-3-(trifluoromethyl)benzeneethanamine or of a salt thereof with an organic or inorganic salt by catalytic hydrogenation and, optionally, the salification with hydrochloric acid.</p> |
申请公布号 |
EP0882700(A2) |
申请公布日期 |
1998.12.09 |
申请号 |
EP19970115338 |
申请日期 |
1997.09.04 |
申请人 |
ALFA CHEMICALS ITALIANA S.P.A. |
发明人 |
CANNATA, VINCENZO;BIANCHI, STEFANO;SPREAFICO, ANGELO;MASPES, BARBARA |
分类号 |
C07C209/68;B01J23/44;C07B61/00;C07C209/08;C07C211/26;C07C211/29;C07C211/63;(IPC1-7):C07C211/26 |
主分类号 |
C07C209/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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