发明名称 |
Optical resolution of primary amines by enantioselective acylation with a long-chain alkoxyalkanoate or phenoxyalkanoate ester in the presence of a lipase |
摘要 |
Process for preparing optically active primary amines comprises: (a) reacting a primary amine with a long-chain alkoxyalkanoate or phenoxyalkanoate ester (I) in the presence of a lipase; and (b) separating the enantioselectively acylated amine from the unreacted amine. Process for preparing optically active primary amines comprises: (a) reacting a primary amine with an ester of formula (I) in the presence of a lipase; and (b) separating the enantioselectively acylated amine from the unreacted amine: m = 0 or 1; R<1> = 6-20C alkyl or 6- to 20-membered heteroalkyl, optionally substituted by 1-5 halogen atoms and/or an oxo group; R<2> = 1-8C alkyl or phenyl; R<3> = H or 1-8C alkyl. An Independent claim is also included for a process for acylating primary amines of formula (II), comprising reacting (II) with (I) in the presence of a lipase: n = 0 or 1; R<4>, R<5> = H, 1-8C alkyl or phenyl; R<6> = 1-6C alkyl or benzyl.
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申请公布号 |
DE19837745(A1) |
申请公布日期 |
2000.02.24 |
申请号 |
DE19981037745 |
申请日期 |
1998.08.20 |
申请人 |
BASF AG |
发明人 |
NUEBLING, CHRISTOPH;DITRICH, KLAUS;DULLY, CHRISTIAN |
分类号 |
C07C213/08;C07C217/08;C12P13/02;C12P41/00;(IPC1-7):C12P41/00;C07C209/88;C07B57/00 |
主分类号 |
C07C213/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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