<i>Fusobacterium </i>polypeptides and methods of use

摘要

The present invention provides isolated polypeptides isolatable from a Fusobacterium spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.

主权项

1. A composition comprising an isolated whole cell preparation of a Fusobacterium spp., wherein the cells comprise at least two meta regulated polypeptides having molecular weights between 76 kDa and 86kDa, between 62 kDa and 68 kDa, between 45 kDa and 53 kDa, between 34 kDa and 43 kDa, or between 24 kDa and 35 kDa, wherein molecular weight is determined by eiectrophoresis on a sodium dodecyl sulfate-polyacrylamide gel, wherein the metal regulated polypeptides are natively expressed by a Fusobacterium spp. when incubated in medium that includes a metal chelator and not natively expressed at a detectable level when grown in the medium in the absence of a metal chelator and further comprising an adjuvant.