BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2

摘要

The present invention relates to new benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions thereof, and methods of use thereof.;

主权项

1. A method of treating a VMAT2-mediated disorder comprising administering to a subject in need of treatment a dosage unit comprising a therapeutically effective amount of a compound of the formula: or a salt or diasteromer thereof, wherein: each position designed as D has deuterium enrichment above the naturally occurring distribution of deuterium; and the administration results in decreased average plasma levels in the subject of at least one metabolite of said compound, as compared to administration of the corresponding non-deuterium enriched compound.