| 摘要 |
<p>PURPOSE:To enable high-efficiency production of optically active citronellic acid derivative which is useful as a starting material for medicines, agrochemicals and perfumes from a cyclopentane derivative through a shortened process. CONSTITUTION:The reductive fission of a compound of formula II [R<2> is H, OH-protecting group; X' is H, alkyl (may be substituted), aryl (may be substituted), OR<3>, SR<4>, NR<3>R<4>, R<2> and X' may form a single bond; Y is halogen, SR<5>, SeR<5>; R<3> to R<5> are H, alkyl (may be substituted), aryl (may be substituted); wavy line represents that any configuration may be possible] or its antipode is carried out in the presence of a reducing agent, for example, metal such as Zn, Sn or Mg or a hydrogenated tin compound such as R<6>R<7>R<8>SnH (R<6> to R<8> are alkyl, aryl) or a samarium halide such as SmX2<2>' (X2<2>' is Cl, Br, I) in an inactive solvent such as hexamethyltriphosphoric acid triamide at a temperature of from -100 deg.C to +100 deg.C to give the objective optically active product of formula I(R<1> is each group among R<2>, X is each group among X').</p> |
