发明名称 |
STABILIZED WATER-IN-OIL-IN-WATER ANTIGEN DELIVERY SYSTEM |
摘要 |
A water-in-oil-in-water (W/O/W) emulsion to be used in an antigen delivery system to induce rapid and long-lasting immunity among populations of livestock, birds, and fish. The external aqueous phase of the W/O/W emulsion contains a thixotropic inorganic salt, such as aluminum hydroxide or alum. The presence of the inorganic salt helps to elicit both a Th1 and a Th2 response from the subject's immune system, and the thixotropic properties of the salt stabilize the water-in-oil-in-water emulsion, thereby providing a longer vaccine shelf life. The antigen dose to be delivered to the subject may be contained in entirely in the internal aqueous phase. Alternatively, a first portion of the total antigen dose may be included in the internal aqueous phase and a second portion is included in the external aqueous phase. The incorporation of a portion of the antigen in the external aqueous phase triggers a more uniform immune response across a vaccinated population. The W/O/W based vaccines can be administered either by injection or orally.
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申请公布号 |
WO0037045(A2) |
申请公布日期 |
2000.06.29 |
申请号 |
WO1999US30500 |
申请日期 |
1999.12.20 |
申请人 |
MAINE BIOLOGICAL LABORATORIES, INC. |
发明人 |
SNOW, WILLIAM, C.;GOGAN, WALTER, C. |
分类号 |
A61K9/00;A61K9/113;(IPC1-7):A61K9/00 |
主分类号 |
A61K9/00 |
代理机构 |
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