| 摘要 |
The compositions comprise one or more orally deliverable dose units, each of them comprising a selective cyclooxygenase-2 inhibitory compound of low water solubility in therapeutically effective amounts, wherein the compound is present in the form of solid particles, about 25 to 100 percent by weight, which are smaller than 1 mm. The compositions are useful in the treatment or prophylaxis of conditions and disorders mediated by cyclooxygenase-2, and are particularly advantageous when rapid therapeutic effect is desired. The novel crystalline forms of celecoxib are describedû Form I and Form II, which possess unique chemical and physical properties relating to other solid state forms of celecoxib, and are characterized by their powder X-ray diffraction (PXRD) patterns, differential scanning calorimetric (DSC) thermograms, and other physical characteristics.
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