| 摘要 |
<p>4-Carboxamido-benzimidazole derivatives (I) containing a sterically hindered amine in position 2, and their salts are new. 4-Carboxamido-benzimidazole derivatives (I) (structure not given) containing a sterically hindered amine in position 2, and their salts are new. R 1H, 1-4C alkyl or 1-4C alkoxy; R 2H, 1-4C alkyl, carboxy, 1-4C alkoxycarbonyl, carboxamido or (hetero)aryl; R 3H, 1-4C alkyl, aryl-methylene or aryl; Y 1bond, 1-4C alkene, carbonyl-amino-1-4C alkene or S-(CH 2) m; n : 0 or 1; m : 1-3; Q : H, hydroxy, oxygen or N=O (oxoammonium) group formed with N atom present in the ring; and Z' : single or double bond. The all alkene groups are optionally interrupted by an arylene. ACTIVITY : None given. MECHANISM OF ACTION : Poly(ADP-ribose) polymerase (PARP) inhibitor. No biological data given.</p> |
